Protein Details: Aquaporin-5
Protein ID
ICDB_Pro_0540
Protein Name
Aquaporin-5
Gene Name
Aqp5
Organism
Rattus norvegicus (Rat)
Length
265 amino acids
AlphaFoldDB
AF-P47864-F1-model_v4.pdb
Function
Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4;controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye;lung and in sweat glands (By similarity).
Sequence
MKKEVCSLAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAVFYVAAQLVGAIAGAGILYWLAPLNARGNLAVNALNNNTTPGKAMVVELILTFQLALCIFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAMLAAILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH
PDB Structures
Ligand Binding
Binding Site
Disease
Schistosomiasis; Sepsis
Location
Salivary glands;lacrimal glands;corneal epithelium in eye;trachea and lung
DOI ID
10.1074/jbc.270.4.1908; 10.1101/gr.2596504
RefSeq
NP_036911.1